NIFTP Categorization of the Thyroid Lesions, A New Concept Versus Papillary Carcinoma with IHC Markers (HBME-1, CK-19, CD56 AND P63)

NIFTP Categorization of the Thyroid Lesions, A New Concept Versus Papillary Carcinoma with IHC Markers (HBME-1, CK-19, CD56 AND P63)
 

Dr. Shamoon Sulthana MD *¹, Dr. Srikanth Babu MD ²

1. Department of Pathology, Kaloji Narayana Rao University of Health Sciences Warangal, Telangana.
2. Professor, Department of Pathology SVS Medical College, Mahbubnagar, Telangana.

*Correspondence to: Dr. Shamoon Sulthana. Kaloji Narayana Rao University of Health Sciences Warangal, Telangana.

Copyright

© 2026 Dr. Shamoon Sulthana. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: 25 April 2026

Published: 12 May 2026

DOI: https://doi.org/10.5281/zenodo.20132323

List of Abbreviations

PTC – Papillary Carcinoma Thyroid

NIFTP– Non-invasive Follicular neoplasm with papillary Like Nuclear Features

FT – UMP – Follicular Tumor with Uncertain Malignant Potential

WDT– UMP – well Differentiated Tumor with Uncertain Malignant potential

H and E – Haematoxylin and Eosin

IHC – Immunohistochemistry

CK – 19  -  Cytokeratin - 19

HBME –1 - Hector Battifora Mesothelial - 1

ICD – International Classification of Diseases

EPON - Encapsulated papillary oncocytic neoplasms

+VE - Positive

-VE - Negative

Introduction

Thyroid malignancy is the most common endocrine malignancy.[1] Majority of thyroid tumors are primary and epithelial. They are preferably divided into 3 major categories depending on the cell types involved.

1. Tumors exhibiting follicular cell differentiation
2. Tumors e